both of these errors suggest a problem with your config file...
SMTP Error (554): Failed to add recipient "user@domain.com" (5.7.1 <localhost[127.0.0.1]>: Client host rejected: Access denied).
you need to setup SMTP auth, look for smtp_user and smtp_pass in your roundcube config.
PHP Error: Failed to load plugin file /var/lib/roundcube/plugins//.php...
what is the plugins directive set to in your roundcube config? the error suggests to me that you might have put an empty string in there, thats wrong. for no plugins it should just be an empty array.