I increased Sendmail log level and saw this.
Jan 31 09:56:58 bayou sendmail[1207234]: 00VGuwxX1207234: AUTH failure (GSSAPI): generic failure (-1) SASL(-1): generic failure: GSSAPI Error: Unspecified GSS failure. Minor code may provide more information (Key table file '/etc/krb5.keytab' not found), relay=localhos>
I saw GSSAPI and noticed it in sendmail.mc, so I removed it. Now it works. Something changed in Roundcube as this setting worked in previous versions. But, I don't even know what GSSAPI does anyway. I've had that setting in Sendmail for years.
Thank you,
Durwin